The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of metoprolol succinate and telmisartan in combined tablet dosage form. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectra was obtained in methanol and the determinations were made at 219.2nm (ZCP of telmisartan) for metoprolol succinate and 238nm (ZCP of metoprolol succinate) for telmisartan. The linearity was obtained in the concentration range of 4-14μg/ml for metoprolol succinate and 1-6 μg/ml for telmisartan. The mean recovery was 99.6 ± 0.26and 99.43 ± 0.32 for metoprolol succinate and telmisartan, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of metoprolol succinate and telmisartan in pharmaceutical tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
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